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Related Experiment Videos

The current perception thresholds in normal pregnancy.

Shoichi Watanabe1, Yasuo Otsubo, Tsutomu Araki

  • 1Department of Obstetrics and Gynaecology, Nippon Medical School, Japan.

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
|August 21, 2002
PubMed
Summary

Pregnancy alters pain perception, with higher nociceptive thresholds found at term. This change in current perception threshold (CPT) correlates with the ratio of 17 beta-estradiol to progesterone, suggesting hormonal influences on pain sensitivity.

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Area of Science:

  • Neuroscience
  • Reproductive Endocrinology
  • Pain Research

Background:

  • Pain perception and nociceptive thresholds can be influenced by hormonal fluctuations.
  • Pregnancy involves significant hormonal changes, particularly in ovarian sex steroids like 17 beta-estradiol (E2) and progesterone (P).
  • Understanding these changes is crucial for managing pain during pregnancy and postpartum.

Purpose of the Study:

  • To quantitatively analyze nociceptive thresholds using current perception threshold (CPT) in pregnant women.
  • To investigate the relationship between these nociceptive thresholds and serum concentrations of 17 beta-estradiol (E2) and progesterone.
  • To explore potential correlations with the E2/P ratio.

Main Methods:

  • Quantitative sensory testing using a Neurometer CPT/C device to measure ankle CPTs at 5, 250, and 2,000 Hz.

Related Experiment Videos

  • Blood sample collection for serum measurement of total 17 beta-estradiol (E2) and progesterone concentrations.
  • Comparison of CPTs between 10 women in normal singleton pregnancies (at term) and 14 age-matched nonpregnant controls.

    • Main Results:

    • Significantly higher CPTs at 2,000 Hz were observed in term pregnant women compared to nonpregnant controls (p<0.05).
    • No significant differences in CPTs were found at 5 Hz and 250 Hz between the groups.
    • A significant positive correlation was found between CPT at 2,000 Hz and the E2/P ratio (p<0.05, r=0.67), but not with individual E2 or P levels.

    Conclusions:

    • Nociceptive thresholds, specifically at 2,000 Hz, are altered at term in normal pregnancies, indicating changes in pressure sensitivity.
    • While direct correlations with E2 and P were not found, the E2/P ratio is significantly associated with these altered thresholds.
    • Hormonal factors, potentially influenced by both E2 and P, likely play a role in modulating pain perception during late-term pregnancy.