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Related Experiment Videos

Dengue infection: a global concern.

Chitsanu Pancharoen1, Wanla Kulwichit, Terapong Tantawichien

  • 1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|August 22, 2002
PubMed
Summary

Dengue fever is a significant mosquito-borne viral disease affecting tropical regions. Early recognition and supportive care are crucial for managing severe dengue hemorrhagic fever (DHF) and preventing shock.

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Area of Science:

  • Virology
  • Tropical Medicine
  • Public Health

Background:

  • Dengue virus infection is a major global health concern, particularly in tropical areas.
  • The disease spectrum ranges from mild symptoms to severe dengue hemorrhagic fever (DHF), characterized by bleeding and shock.
  • Increasing reports highlight unusual neurological and hepatic manifestations of dengue.

Purpose of the Study:

  • To provide a comprehensive overview of dengue infection, including its clinical spectrum, diagnosis, and management.
  • To emphasize the importance of early diagnosis and supportive care in managing severe dengue cases.
  • To highlight the need for further research into dengue pathogenesis for vaccine development.

Main Methods:

  • Review of clinical manifestations, including fever, bleeding diathesis, and shock.

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  • Discussion of hematological findings such as vasculopathy, coagulopathy, and thrombocytopenia.
  • Overview of diagnostic methods including virus isolation, serology, and RNA detection.

    • Main Results:

    • Dengue presents with diverse clinical symptoms, from asymptomatic cases to severe DHF.
    • Key hematological findings in DHF include vasculopathy, coagulopathy, and thrombocytopenia.
    • Unusual presentations, particularly cerebral and hepatic, are increasingly reported.

    Conclusions:

    • Effective dengue management relies on early detection and supportive treatment to prevent shock.
    • Vector control remains the primary prevention strategy.
    • Further research into DHF pathogenesis is essential for developing effective vaccines.