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Related Experiment Videos

Hepatic dysfunction in dengue patients with various severity.

Chitsanu Pancharoen1, Atchara Rungsarannont, Usa Thisyakorn

  • 1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|August 22, 2002
PubMed
Summary

Biochemical changes in liver function, specifically elevated transaminase and lower globulin levels, correlate with severe dengue infection in children. These findings highlight hepatic dysfunction as a common complication in pediatric dengue cases.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Dengue infection can lead to significant biochemical alterations.
  • Hepatic dysfunction is a recognized complication of dengue, particularly in severe forms.
  • Understanding these changes is crucial for managing pediatric dengue patients.

Purpose of the Study:

  • To investigate the relationship between biochemical markers of liver function and the severity of dengue infection in children.
  • To identify specific liver function test abnormalities associated with severe dengue manifestations like dengue shock syndrome.

Main Methods:

  • A prospective study involving 104 pediatric patients with confirmed dengue infection.
  • Patients were categorized into non-shock (dengue fever, dengue hemorrhagic fever) and shock (dengue shock syndrome) groups.

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  • Liver function tests were conducted within three days post-defervescence or shock resolution.

    • Main Results:

    • Significantly elevated aspartate transaminase (AST) and alanine transaminase (ALT) levels were observed in patients with more severe dengue.
    • Globulin levels were significantly lower in children with severe dengue infection.
    • No significant differences were found in albumin, alkaline phosphatase, bilirubin, or prothrombin time between severity groups.

    Conclusions:

    • Hepatic dysfunction is a frequent occurrence in pediatric dengue patients.
    • Higher transaminase levels and lower globulin levels are indicative of more severe dengue disease.
    • These biochemical markers can aid in assessing disease severity and guiding clinical management.