Related Experiment Video

Updated: Jul 11, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Epitope mapping of ligand-receptor interactions by diffusion NMR

Jiangli Yan1, Allen D Kline, Huaping Mo

  • 1Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Journal of the American Chemical Society
|August 22, 2002
PubMed

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Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
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Two-Dimensional (2D) NMR: Overview

The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
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2D NMR: Overview of Homonuclear Correlation Techniques

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2D NMR: Overview of Heteronuclear Correlation Techniques

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