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Related Experiment Videos

Antisense anticancer oligonucleotide therapeutics.

H Wang1, G Prasad, J K Buolamwini

  • 1Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, Cancer Pharmacology Laboratory, Comprehensive Cancer Center, and Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Current Cancer Drug Targets
|August 22, 2002
PubMed
Summary

Antisense therapy, a genetic treatment, uses antisense oligonucleotides to block disease-causing genes. This review covers its development from lab to clinic, highlighting its promise for cancer treatment.

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Area of Science:

  • Molecular Biology
  • Biotechnology
  • Genetics
  • Genetic Therapy

Background:

  • Advances in gene identification and characterization have enabled genetic therapies.
  • Antisense therapy utilizes antisense oligonucleotides to inhibit pathogenic gene expression by targeting mRNA.
  • This approach offers specific, rational, and genetic-based therapeutic strategies.

Purpose of the Study:

  • To review the development of antisense therapy from preclinical to clinical stages.
  • To highlight the progress and potential of antisense oligonucleotides as therapeutic agents.
  • To discuss key considerations in developing antisense drugs, including target selection and chemistry.

Main Methods:

  • Review of preclinical and clinical studies on antisense oligonucleotides.

Related Experiment Videos

  • Examination of specific cancer targets (e.g., bcl-2, BCR-ABL, p53) for antisense therapy.
  • Discussion of advanced antisense chemistry and drug development approaches.

    • Main Results:

    • Significant progress in antisense therapy development over the past decade.
    • Approval of the first antisense drug for clinical use.
    • Demonstrated potential of antisense oligonucleotides in targeting various cancer-related genes.

    Conclusions:

    • Antisense therapy represents a promising frontier in genetic-based therapeutics.
    • Effective target selection and advanced chemistry are crucial for successful antisense drug development.
    • The field shows considerable potential, particularly for human cancer therapy.