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Drug target discovery by gene expression analysis: cell cycle genes
1Incyte Genomics and Department of Medicine, Stanford University, 1475 Flamingo Way, Sunnyvale, CA, USA. mwalker@stanfordalumni.org
Current Cancer Drug Targets
|August 22, 2002
Summary
Gene expression analysis aids drug discovery by identifying novel cell cycle genes. This study highlights the discovery of CDCA1-CDCA8, co-expressed with known cell cycle regulators.
Area of Science:
- Genomics
- Molecular Biology
- Pharmacology
Background:
- Gene expression microarrays and databases offer novel avenues for drug target identification.
- Understanding drug mechanisms of action is crucial in pharmaceutical research.
Purpose of the Study:
- To review gene expression analysis methods for drug target discovery.
- To identify novel human cell cycle genes using expression data.
Main Methods:
- Differential gene expression analysis.
- Co-expression network analysis.
- Utilizing gene expression databases and microarrays.
Main Results:
- Identification of previously unrecognized human cell cycle genes (CDCA1-CDCA8).
- Demonstrated co-expression of these novel genes with known cell cycle genes (e.g., CDC2, CDC7, cyclin).
Conclusions:
- Gene expression analysis is a powerful tool for discovering novel drug targets.
- The identified CDCA genes represent potential targets for therapeutic intervention in cell cycle-related diseases.