Predictors of refractory tachycardia in infants with supraventricular tachycardia

Reentrant supraventricular tachycardia (SVT) is the most common arrhythmia in infants. There are few predictors as to which patients will have recurrent or refractory SVT. We retrospectively reviewed records of all infants with SVT evaluated at The Hospital for Sick Children, Toronto, between January 1, 1995, and December 31, 1999. Patients with reentrant SVT documented in infancy and structurally normal hearts were included. Patients were placed in two groups: the "simple" group consisted of patients with SVT completely controlled by not more than one medication, and the "complex" group consisted of patients with recurrent episodes requiring at least one medication change for control. Forty-two cases were analyzed-23 in the simple group and 19 in the complex group. One patient in each group died. Age at presentation was 50.4 +/- 13.2 days for the simple group versus 10.2 +/- 2.5 days for the complex group (p <0.01). Complex patients were treated with a median of three medications and were more likely to have echocardiographically reduced ventricular function. The surface electrocardiogram RP interval during SVT was significantly longer in complex patients (p <0.001). There were no differences between the groups in gender, cycle length in SVT or sinus rhythm, the presence of pre-excitation, initial medication choice, or duration of therapy. Recurrent SVT in infancy is associated with younger age and/or ventricular dysfunction at presentation and also with slower ventriculoatrial conduction. The similar duration of therapy for simple and complex patients suggests that the early clinical course of SVT in infancy is not predictive of long-term outcome.