Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vasculitis induced by zafirlukast therapy.

M Soy1, H Ozer, A Canataroglu

  • 1Department of Rheumatology-Immunology, Cukurova University Faculty of Medicine, Adana, Turkey.

Clinical Rheumatology
|August 22, 2002
PubMed
Summary

Zafirlukast, a new asthma medication, is linked to Churg-Strauss syndrome. This case report details a patient developing vasculitis, hepatitis, and eosinophilia while on zafirlukast.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation of the Frequency of CRP Gene Polymorphism in Rheumatoid Arthritis and Associations with CRP Level and Clinical Involvements of the Disease.

Balkan journal of medical genetics : BJMG·2025
Same author

Efficacy of pulmonary rehabilitation in patients with post-acute COVID-19.

European review for medical and pharmacological sciences·2023
Same author

Inflammatory rheumatic diseases developed after COVID-19 vaccination: presentation of a case series and review of the literature.

European review for medical and pharmacological sciences·2023
Same author

Could immune cells be associated with nephropathy in Fabry disease patients?

International urology and nephrology·2023
Same author

Diagnostic value of MDCT in determining the perinephric fat tissue and renal sinus invasion in patients with clear cell renal cell carcinoma.

Nigerian journal of clinical practice·2021
Same author

Colonic fibronectin and E-cadherin in mild ulcerative colitis.

Bratislavske lekarske listy·2021

Area of Science:

  • Pulmonology
  • Immunology
  • Gastroenterology

Background:

  • Zafirlukast is a leukotriene receptor antagonist approved for asthma prophylaxis.
  • It is generally well-tolerated with convenient dosing and few side effects.
  • However, rare cases of Churg-Strauss syndrome have been associated with its use.

Observation:

  • A 54-year-old male patient with mild asthma was treated with zafirlukast.
  • The patient had no prior history of corticosteroid therapy.
  • He developed symptoms including leukocytoclastic vasculitis, hepatitis, and eosinophilia.

Findings:

  • The patient's symptoms emerged during zafirlukast therapy.
  • The clinical presentation mimicked aspects of Churg-Strauss syndrome.
  • This case highlights a potential adverse drug reaction to zafirlukast.

Related Experiment Videos

Implications:

  • Clinicians should be aware of the potential for zafirlukast-associated vasculitis, hepatitis, and eosinophilia.
  • Early recognition and management are crucial for patients on zafirlukast.
  • Further investigation into the mechanism of zafirlukast-induced adverse events is warranted.