Related Experiment Video
Updated: Sep 29, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Effect of cyclosporin A treatment on renal calcium oxalate binding in experimental hyperoxaluria
Marimuthu Adhirai1, Ramasamy Sakthivel, Ramasamy Selvam
1Department of Medical Biochemistry, Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India.
Abstract:
This study was aimed to investigate the effect ofCyclosporin A administration on renal calcium oxalate binding under hyperoxaluric condition. Cyclosporin A administration or ammonium oxalate treatment increased calcium oxalate binding, which was further increased in kidney treated with cyclosporin A and ammonium oxalate together. The increase of calcium oxalate binding was associated with lipid peroxidation as well as with a concomitant decrease in total thiol in both rat and human kdiney homogenate. Cyclosporin A administration to hyperoxaluric rats resulted with increased calcium oxalate binding protein. However there was no change with specific activity of the protein. In conclusion, Cyclosporin A administration either to normal or hyperoxaluric rats is resulted with increased concentration of calcium oxalate binding protein as well as enhanced activity due to membrane lipid peroxidation.
Related Concept Videos
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Renal Drug Excretion: Tubular Secretion
Urinary Tract Calculi III: Medical Management
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
Drug Elimination by Renal Route: Tubular Reabsorption
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant