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Human orf.

J V Johannessen, H K Krogh, I Solberg

    Journal of Cutaneous Pathology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Human orf, a rare viral disease from sheep and goats, commonly presents with erythema multiforme. Electron microscopy of lesions offers the quickest diagnosis for this pox virus infection.

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    Area of Science:

    • Veterinary Medicine
    • Human Infectious Diseases
    • Virology

    Background:

    • Human orf is a zoonotic infection caused by a paravaccinia virus, typically transmitted from sheep and goats.
    • While considered rare, understanding its clinical spectrum and diagnostic approaches is crucial.

    Purpose of the Study:

    • To present findings from 119 new human orf cases.
    • To detail epidemiological, clinical, histopathological, and ultrastructural characteristics.
    • To evaluate diagnostic methods for human orf.

    Main Methods:

    • Collection and analysis of data from 119 human orf cases.
    • Clinical examination and histopathological assessment of lesions.
    • Ultrastructural analysis using electron microscopy.

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    Main Results:

    • Erythema multiforme frequently complicated human orf cases.
    • Overtreatment was identified as a cause of other complications.
    • Electron microscopy of lesion suspensions proved to be the most rapid and effective diagnostic tool.

    Conclusions:

    • Human orf presents with diverse clinical manifestations, including erythema multiforme.
    • Careful management is needed to avoid complications from overtreatment.
    • Electron microscopy is the preferred diagnostic method for rapid identification of the paravaccinia virus in orf lesions.