Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The thymus and negative selection.

Jonathan Sprent1, Hidehiro Kishimoto

  • 1Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037, USA. jsprent@scripps.edu

Immunological Reviews
|August 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut microbiota bidirectionally influences protection and severity in cerebral malaria in mice.

Tropical medicine and health·2026
Same author

IL-2 Complex Therapy Mitigates Humoral Rejection of Fully Mismatched Skin Allografts by Inhibiting IgG Alloantibody Formation.

Cells·2025
Same author

Characterization of Lachnoanaerobaculum sanguinis sp. nov., isolated from a blood culture of an acute myeloid leukemia patient with chemotherapy-related bacteremia.

Anaerobe·2025
Same author

IL-15: from discovery to FDA approval.

Journal of hematology & oncology·2025
Same author

In vivo imaging of adipose-derived stem cell sheets on biodegradable nonwoven fabric using X-ray CT.

Biomedical engineering online·2024
Same author

Shape of scaffold controlling the direction of cell migration.

Biophysics and physicobiology·2024

Central tolerance prevents autoimmune diseases by eliminating self-reactive T cells during development. This process, known as negative selection, occurs in the thymus and affects semimature T cells, influenced by costimulatory molecules, Fas, and cytokines.

Area of Science:

  • Immunology
  • T cell biology
  • Autoimmunity

Background:

  • Maintaining self-tolerance is crucial for preventing autoimmune diseases.
  • Central tolerance, including negative selection in the thymus, eliminates self-reactive T cells during T cell development.
  • Peripheral tolerance mechanisms also contribute to self-tolerance.

Purpose of the Study:

  • To review evidence supporting negative selection occurring in the thymic medulla.
  • To identify the specific T cell population affected by thymic negative selection.
  • To discuss the roles of costimulatory molecules, Fas, and cytokines in this process.

Main Methods:

  • Review of existing scientific literature and evidence.
  • Analysis of T cell development and selection processes within the thymus.

Related Experiment Videos

  • Discussion of molecular and cellular factors influencing negative selection.

    • Main Results:

    • Negative selection of T cells can occur in the thymic medulla.
    • A population of semimature HSA+ T cells is affected by thymic negative selection.
    • Costimulatory molecules, Fas, and cytokines play significant roles in regulating negative selection.

    Conclusions:

    • Thymic medulla is a key site for T cell negative selection.
    • Semimature HSA+ T cells are important targets for central tolerance induction.
    • Understanding these mechanisms is vital for managing autoimmune conditions and improving T cell therapies.