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Statins decrease bone turnover in postmenopausal women: a cross-sectional study.

L Rejnmark1, N H Buus, P Vestergaard

  • 1Department of Endocrinology and Metabloism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark. rejnmark@post6.tele.dk

European Journal of Clinical Investigation
|August 23, 2002
PubMed
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Statins appear to reduce bone turnover, suggesting an antiresorptive effect in postmenopausal women. While statin use lowers bone turnover markers and increases parathyroid hormone (PTH), it did not significantly impact bone mineral density in this study.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Statins are investigated for osteoporosis management.
  • Medical record reviews suggest increased bone mass and reduced fractures with long-term statin use.
  • This study investigates statins' effects on calcium homeostasis, bone turnover, and bone mineral density.

Purpose of the Study:

  • To evaluate the impact of long-term statin treatment on bone turnover markers, parathyroid hormone (PTH) levels, and bone mineral density (BMD).
  • To explore potential antiresorptive effects of statins in postmenopausal women.

Main Methods:

  • Cross-sectional study comparing 140 postmenopausal women on statins (≥2 years) with 140 matched controls.
  • Measured plasma levels of PTH, bone turnover markers (osteocalcin, bone-specific alkaline phosphatase, C-terminal telopeptide of type I collagen).

Related Experiment Videos

  • Assessed bone mineral density (BMD) and body composition.

    • Main Results:

    • Statin users showed significantly lower bone turnover markers (osteocalcin, bone-specific alkaline phosphatase, C-terminal telopeptide of type I collagen).
    • Plasma PTH levels were significantly higher in statin-treated subjects.
    • No significant differences in body composition or BMD at various skeletal sites were observed between groups.
    • No correlation found between biochemical changes and statin dose or duration.

    Conclusions:

    • Statins demonstrably affect bone cell function.
    • The observed effects suggest an antiresorptive mechanism of action for statins on bone metabolism.
    • Further research may clarify the clinical implications for osteoporosis management.