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Bcr-Abl variants: biological and clinical aspects
Anjali S Advani1, Ann Marie Pendergast
1Departments of Hematology and Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Leukemia Research
|August 23, 2002
Abstract:
Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis.