Does hypertension alone lead to cognitive decline in spontaneously hypertensive rats?

Spontaneously hypertensive rats (SHR) represent an animal model of cognitive decline associated with hypertension. Few studies have systematically investigated this decline in aging. We assessed spatial learning performances of SHR, the genetically similar Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD), in a water maze (WM) task. The following age ranges were studied: 6, 12, and 20 months. The results demonstrated that all three strains show the same level of impairment at the age of 20 months. The rate of cognitive decline, however, is different: both SHR and WKY show moderate degrees of impairment at all age ranges, while SD display good cognitive abilities at 6 months, declining at 12, and reaching the performance level of the other two groups at 20 months. Besides, the nine groups showed substantial differences in swim velocity and WKY exhibited a peculiar motor behavior. These results suggest the following: (a) the decline in cognitive level exhibits different trends in the three strains; (b) learning impairment of aged SHR might not be entirely explained by hypertension; (c) WKY should be used cautiously as normotensive control for SHR, due to their unusual behavior and low learning abilities; (d) analysis of escape distances is mandatory for the comparison of different strains in the WM test.