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Related Experiment Videos

Injectable hormone contraception and bone density: results from a prospective study.

Delia Scholes1, Andrea Z LaCroix, Laura E Ichikawa

  • 1Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA. scholes.d@ghc.org

Epidemiology (Cambridge, Mass.)
|August 23, 2002
PubMed
Summary

Depot medroxyprogesterone acetate (DMPA) injectable contraception use is linked to bone density loss. However, bone density significantly recovers after discontinuing DMPA, suggesting reversible effects.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Reproductive Health

Background:

  • Depot medroxyprogesterone acetate (DMPA) injectable contraception is associated with decreased bone density and potential osteoporosis risk.
  • Prospective data on DMPA's long-term bone effects and reversibility after discontinuation are limited.

Purpose of the Study:

  • To investigate the impact of DMPA use on bone density.
  • To assess bone density changes after DMPA discontinuation.

Main Methods:

  • A population-based prospective cohort study involving 457 women aged 18-39 (183 DMPA users, 274 non-users).
  • Bone density was measured using dual-energy x-ray absorptiometry every 6 months for 3 years.

Main Results:

  • DMPA users experienced significant bone density loss at the spine and total hip compared to non-users.

Related Experiment Videos

  • Women who discontinued DMPA showed substantial increases in bone density at both sites.
  • After 30 months, bone density in DMPA discontinuers was comparable to that of non-users.

    • Conclusions:

    • DMPA use is strongly associated with bone density reduction.
    • Bone density loss associated with DMPA appears largely reversible upon discontinuation.