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Related Experiment Videos

Reference values for transverse cerebellar diameter throughout gestation.

Halit Pinar1, Sarah H Burke, Carol W Huang

  • 1Developmental Pathology Program, Women and Infants Hospital of Rhode Island and Brown Medical School, 101 Dudley Street, Providence, RI 02905, USA. hpinar@wihri.org

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|August 23, 2002
PubMed
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This study establishes normal values for the transverse cerebellar diameter (TCD) in pathology specimens. These TCD values correlate well with ultrasound findings, confirming TCD

Area of Science:

  • Obstetrics and Gynecology
  • Fetal Development
  • Diagnostic Imaging

Background:

  • The transverse cerebellar diameter (TCD) is a validated ultrasound parameter for estimating gestational age.
  • The cerebellum is often spared in fetal growth restriction, maintaining TCD's reliability.
  • Existing literature primarily relies on ultrasound for TCD-based gestational age estimation.

Purpose of the Study:

  • To establish normative reference values for the transverse cerebellar diameter (TCD) using pathology specimens.
  • To assess the correlation between TCD measurements from pathology specimens and established ultrasound data.
  • To validate TCD as a reliable indicator of gestational age across a wide range of fetal development.

Main Methods:

  • Analysis of 96 human pathology specimens.

Related Experiment Videos

  • Measurement of the transverse cerebellar diameter (TCD) across gestational ages from 14 to 42 weeks.
  • Statistical comparison of pathological TCD measurements with existing ultrasound literature values.

    • Main Results:

    • Established normative TCD values for each gestational week (14-42 weeks) with 2 standard deviations.
    • Demonstrated a strong positive correlation between TCD measurements from pathology specimens and ultrasound-derived data.
    • Confirmed the reliability of TCD as an indicator of gestational age, even in cases of suspected growth restriction.

    Conclusions:

    • Pathology-derived TCD measurements provide reliable reference values for gestational age estimation.
    • The findings support the continued use and validation of TCD in clinical obstetrics.
    • This study bridges the gap between ex vivo and in vivo TCD measurements for fetal assessment.