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Published on: August 10, 2010
[Experimental study on the toxic effects of hydrophilic polyacrylamide gel]
Menghua Huo1, Jinjing Huang, Keming Qi
1Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100041, China.
Objective:
To study the safety of Hydrophilic polyacrylamide gel (HPAG) through an animal experiment.
Methods:
After HPAG was injected underneath the skin of SD rats, tissue specimens were taken for general and histological examinations. The cytotoxicity was evaluated by agar coverage and MTT method.
Results:
It was determined that the cytotoxicity was over level-two. The toxicity to kidney was obvious. The local histological reaction was slight and a thin fibrous membrane was formed around HPAG, which became stiff gradually. The shape and location of the injected HPAG was not stable. The HPAG could not be drawn out completely.
Conclusion:
HPAG has obvious cytotoxicity and is not a suitable material as soft tissue implant for the bad shape and texture.
