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Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure
Margaret P Chandler1, William C Stanley, Hideaki Morita
1Department of Medicine, Henry Ford Heart and Vascular Institute, Detroit, Mich 48202, USA.
Circulation Research
|August 24, 2002
Abstract:
The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MVO2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased MVO2 and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in MO2, resulting in an increased myocardial mechanical efficiency in dogs with HF.