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Initial neural net construction for the detection of cervical intraepithelial neoplasia by fluorescence imaging
Mary F Parker1, Gregory C Mooradian, Gordon S Okimoto
1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC, USA.
Objective:
The aim of this study was to initiate neural net construction for the detection of cervical intraepithelial neoplasia by fluorescence imaging.
Study Design:
Thirty-three women with abnormal Papanicolaou smears underwent fluorescence imaging during colposcopy. With the use of >4000 training pixels and >1000 test pixels, intrapatient nets were constructed from the spectral data of 17 women. An interpatient net that discriminated between cervical intraepithelial neoplasia 1 and normal tissue classes among patients was constructed with the use of >2300 training pixels and >2000 test pixels from 12 women. Average correct classification rates were determined. Sensitivities, specificities, and positive and negative predictive values for cervical intraepithelial neoplasia grade 1 and normal tissue classes were calculated. Extrapolated false-color cervical images were generated.
Results:
Average correct classification rates were 96.5% for the intrapatient nets and 97.5% for the interpatient net. The sensitivity, specificity, and positive and negative predictive values for cervical intraepithelial neoplasia grade 1 were 98.2%, 98.9%, 71.4%, and 99.9%, respectively.
Conclusion:
Initial results suggest that neural nets that are constructed from fluorescence imaging spectra may offer a potential method for the detection of cervical intraepithelial neoplasia.