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Updated: Jul 30, 2026

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Published on: September 5, 2017
Biophysical analysis of radiation induced initial DNA fragmentation
I K Khvostunov1, S G Andreev, YuA Eidelman
1Medical Radiological Research Centre, Koroleva str. 4, 240020 Obninsk, Kaluga Region, Russia.
Abstract:
Production of double strand breaks (DSBs) and double-stranded DNA fragments after irradiation with high energy nitrogen ions was simulated with stochastic track generation and a high-order chromatin structure (HOCS) model representing a segment of interphase chromosome. The non-random distribution of DNA fragments is predicted for irradiation of HOCS. Agreement with the experimental data is obtained. The influence of HOCS and the role of the background component in DNA fragment distributions are discussed.

