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Can neostigmine reduce propofol injection pain?
Wei-Wu Pang1, Martin S Mok, Chih-Shung Wang
1Department of Anesthesia, Show-Chwan Memorial Hospital, 542 Chung-Shang Road, Section 1, Changhua, Taiwan, R.O.C. weiwu.pang@msa.hinet.net
Acta Anaesthesiologica Sinica
|August 27, 2002
Summary
Neostigmine provided some pain relief for propofol injections, but lidocaine was more effective. This study investigated neostigmine
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Neostigmine is known to induce peripheral analgesia.
- This study investigated neostigmine's potential to reduce pain associated with propofol injections.
Purpose of the Study:
- To evaluate the peripheral analgesic effect of neostigmine in mitigating propofol injection pain.
- To compare the efficacy of neostigmine with lidocaine and normal saline in reducing propofol injection pain.
Main Methods:
- A double-blind, randomized study involving 105 patients.
- Patients received either neostigmine, lidocaine, or normal saline via venous retention for one minute before propofol injection.
- Pain and side effects were assessed post-injection.
Main Results:
- Propofol injection pain incidence was 85% for saline, 46% for neostigmine, and 6% for lidocaine (P < 0.05).
- Lidocaine demonstrated the strongest analgesic effect, followed by neostigmine, and then normal saline.
Conclusions:
- Neostigmine, with one-minute venous retention, offers a degree of peripheral analgesia for propofol injection pain.
- The analgesic effect of neostigmine was found to be inferior to that of lidocaine.