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B-cell signaling: protein kinase Cdelta puts the brakes on
1Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA. cbcm@joslin.harvard.edu
Current Biology : CB
|August 27, 2002
Abstract:
The phenotype of mice lacking the delta isoform of protein kinase C reveals that this isoform curtails signaling events after engagement of the antigen-specific receptor on B cells. The result is a state of non-responsiveness, termed anergy, that represents one form of immunological self-tolerance.