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Differential regulation of synaptic and extra-synaptic NMDA receptors
Bo Li1, Nansheng Chen, Tao Luo
1Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Nature Neuroscience
|August 27, 2002
Abstract:
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown--the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.