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Metoclopramide-induced supersensitivity psychosis
Mong-Liang Lu1, Jan-Jhy Pan, Hui-Wen Teng
1Department of Psychiatry, Taipei Medical University--Wan Fang Hospital and Taipei Medical University, Taipei, Taiwan.
The Annals of Pharmacotherapy
|August 28, 2002
Summary
Long-term metoclopramide use can lead to supersensitivity psychosis, a condition causing hallucinations and delusions. This first report highlights the risks of chronic dopamine antagonist therapy.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Metoclopramide is a dopamine antagonist commonly used for gastrointestinal disorders.
- Chronic use of dopamine antagonists may lead to dopamine receptor supersensitivity.
Observation:
- Two elderly Taiwanese men developed psychosis after prolonged metoclopramide treatment.
- Symptoms included hallucinations and delusions upon discontinuation of the drug.
Findings:
- This is the first report of metoclopramide-induced supersensitivity psychosis.
- Chronic metoclopramide administration may induce mesolimbic dopamine supersensitivity, leading to psychotic symptoms.
Implications:
- Clinicians must consider the risk of psychosis with long-term metoclopramide therapy.
- Lowest effective doses for the shortest duration are recommended to minimize adverse reactions.