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[Chronic glomerulonephritis with Hb antigen]
Insights
Chronic glomerulonephritis cases were linked to hepatitis B infection. Many patients showed signs of latent chronic hepatitis, suggesting a connection between the virus and kidney disease.
Area of Science:
- Nephrology
- Hepatology
- Virology
Context:
- Investigating the association between chronic glomerulonephritis and hepatitis B virus (HBV) infection.
- Examining HBV antigen (AgHB) and antibody status in patients with kidney disease.
Purpose:
- To explore the prevalence and clinical significance of HBV infection in patients diagnosed with chronic glomerulonephritis.
- To identify patterns of HBV subtypes and their correlation with renal pathology and liver involvement.
Summary:
- A study of nine chronic glomerulonephritis patients revealed 8 with positive hepatitis B antigen (AgHB) and 1 with positive anti-AgHB.
- Five patients had membranous glomerulonephritis, with HBV subtypes 'ad' (6 cases) and 'ay' (2 cases) identified.
- Three family members also tested positive for AgHB, indicating potential familial transmission. Five patients exhibited signs of chronic hepatitis on liver biopsy.
Impact:
- Highlights a frequent association between positive AgHB and clinically latent chronic hepatitis in glomerulonephritis patients.
- Suggests HBV screening may be important for patients with unexplained chronic glomerulonephritis.
- Provides insights into the pathogenesis of HBV-associated kidney disease.
Abstract:
The authors report nine cases of chronic glomerulonephritis with positive hepatitis B antigen (AgHB) (8 cases) and positive anti-AgHb (1 case). Five patients had membranous glomerulonephritis. The sub-type was ad in 6 cases and ay in 2. In 3 members of two families of patients, AgHB was positive with the same sub-type as the subject studied. In 5 cases, liver biopsy showed signs of chronic hepatitis. According to the authors, a positive AgHB in glomerulonephritis is often associated with clinically latent chronic hepatitis.