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Related Experiment Videos

Bioinformatics and type II G-protein-coupled receptors.

S M Foord1, S Jupe, J Holbrook

  • 1Bioinformatics, GlaxoSmithKline, Stevenage, Herts. SG1 2NY, UK. smf3746@ggr.co.uk

Biochemical Society Transactions
|August 28, 2002
PubMed
Summary
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Family B G-protein-coupled receptors (GPCRs) primarily bind peptides. This review classifies the large N-terminal family B seven-transmembrane (LNB 7TM) receptors, a poorly understood group within this GPCR family.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Family B G-protein-coupled receptors (GPCRs) are known for binding peptide ligands.
  • This family includes well-characterized receptors like those for corticotrophin-releasing factor, parathyroid hormone, and secretin.
  • Other receptors, including Frizzled and Smoothened, share homology but may not be G-protein coupled.

Purpose of the Study:

  • To review and highlight similarities among Family B receptors.
  • To provide a classification for the large N-terminal family B seven-transmembrane (LNB 7TM) receptors.
  • To address the limited knowledge regarding LNB 7TM receptors.

Main Methods:

  • Literature review of Family B GPCRs.
  • Analysis of sequence homology and functional characteristics.

Related Experiment Videos

  • Classification based on structural and sequence features.

    • Main Results:

    • Identified similarities across various Family B receptors.
    • Detailed the characteristics of the 33 LNB 7TM receptors, the largest subgroup.
    • Distinguished LNB 7TM receptors from other Family B members and G-protein coupled receptors.

    Conclusions:

    • Family B receptors exhibit diverse characteristics despite shared homology.
    • LNB 7TM receptors represent a significant and understudied class within Family B.
    • Further research is needed to elucidate the specific functions and mechanisms of LNB 7TM receptors.