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Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes
Robert D Hoeldtke1, Kimberly D Bryner, Daniel R McNeill
1Department of Medicine, West Virginia University (WVU), Morgantown, West Virginia 26506-9159, USA.
Diabetes
|August 28, 2002
Summary
Nitric oxide overproduction and nitrosative stress are linked to peripheral nerve damage in type 1 diabetes. This study found that increased nitric oxide (NOx) and nitrotyrosine (NTY) correlate with nerve function decline.
Area of Science:
- Endocrinology
- Neurology
- Biochemistry
Background:
- Type 1 diabetes is a chronic condition affecting blood sugar regulation.
- Peripheral neuropathy is a common complication of diabetes.
- Nitrosative stress, involving nitric oxide, is implicated in diabetic complications.
Purpose of the Study:
- To investigate the association between nitric oxide overproduction and peripheral nerve dysfunction in type 1 diabetes.
- To evaluate nitrosative stress markers and nerve function over three years.
Main Methods:
- Longitudinal study of 37 type 1 diabetes patients over 3 years.
- Measured peripheral nerve function (nerve conduction velocity).
- Assessed biochemical indicators: plasma nitrite/nitrate (NOx), nitrotyrosine (NTY), and uric acid levels.
Main Results:
- Diabetic patients showed significantly higher NOx and NTY levels compared to controls.
- Elevated NTY correlated with decreased motor nerve conduction velocity.
- High NOx levels were associated with reduced sweating, and suppressed uric acid with impaired autonomic function.
Conclusions:
- Nitrosative stress is present in early type 1 diabetes.
- This stress is linked to suppressed uric acid levels.
- Nitrosative stress contributes to the deterioration of peripheral nerve function in type 1 diabetes.