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Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome
R P Allen1, E Mignot, B Ripley
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neurology
|August 28, 2002
Abstract:
Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.