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Published on: December 15, 2011
Pityriasis rubra pilaris in children
Dawn S Allison1, Rokea A El-Azhary, Stella D Calobrisi
1Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Pityriasis rubra pilaris (PRP) in children, often the juvenile form, shows good response to retinoids like isotretinoin. Recurrence occurred in 17% of patients, suggesting retinoids as a key treatment for this rare condition.
Area of Science:
- Dermatology
- Pediatrics
Background:
- Pityriasis rubra pilaris (PRP) is a rare pediatric skin condition.
- Limited long-term data exists on pediatric PRP treatment and prognosis.
Purpose of the Study:
- To review the clinical course and treatment of pediatric PRP cases.
- To evaluate treatment efficacy and long-term outcomes in children with PRP.
Main Methods:
- Retrospective review of 30 pediatric PRP patients (age ≤19) at Mayo Clinic (1975-1997).
- Data collected via chart review and follow-up questionnaires.
Main Results:
- Type III juvenile form was most common.
- Isotretinoin showed the best response, with 5/6 patients achieving 90-100% clearing within 6 months.
- Overall, 43% achieved complete resolution, 23% moderate, and 17% poor response. Recurrence was observed in 17% of those with complete clearing.
Conclusions:
- Pediatric PRP is non-inherited, affects both sexes equally, and commonly presents as the juvenile form.
- Systemic retinoids are recommended as a first-line treatment for pediatric PRP.
- The recurrence rate of 17% highlights the need for ongoing monitoring and management.
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