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Sustained drug release on temperature-responsive poly(N-isopropylacrylamide)-integrated hydroxyapatite
Yongsoon Shin1, Jun Liu, Jeong Ho Chang
1Pacific Nortwest National Laboratory, P.O. Box 999, MSIN K2-44, Richland, WA 99352, USA. yongsoon.shin@pnl.gov
Chemical Communications (Cambridge, England)
|August 29, 2002
Abstract:
A hybrid temperature-responsive hydroxyapatite-poly(N-isopropylacrylamide) (HAP-PNIPAAm) gel has been synthesized by the interpenetration of PNIPAAm into a sintered HAP disk through a radical-initiated polymerization of NIPAAm monomers under N2 atmosphere, and shows sustained positive thermo-responsive drug release profile over a month at PBS buffer.