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[Familial transient red cell aplasia from parvovirus B-19 infection]
Insights
Parvovirus B19 can cause aplastic crisis in children and adults with anemia. Early recognition is key, especially during erythema infectiosum outbreaks, to manage hyperacute anemia effectively.
Area of Science:
- Hematology
- Virology
- Pediatrics
Background:
- Spherocytic hemolytic anemia predisposes individuals to complications.
- Parvovirus B19 is a known cause of transient aplastic crisis.
Observation:
- A child and his mother with spherocytic hemolytic anemia presented with hyperacute anemia.
- Both patients tested positive for Parvovirus B19 IgM antibodies and viral DNA.
Findings:
- The anemia was diagnosed as a transient aplastic crisis induced by Parvovirus B19.
- Treatment involved transfusion of concentrated red blood cells.
Implications:
- Consider Parvovirus B19-induced red cell aplastic crisis in familial hyperacute anemia.
- Awareness is crucial during erythema infectiosum outbreaks for timely diagnosis and management.
Abstract:
In our Paediatric Clinic we observed a case of transient aplastic crisis caused by Parvovirus B19 in a child and his mother, both affected by spherocytic haemolytic anemia. Anti-Parvovirus IgM antibody titre and viral search by PCR were positive. Anemia was treated with transfusion of concentrated red blood cells. In case of a family onset of hyperacute anemia it is necessary to consider a bone marrow aplastic crisis of the red series, induced by Parvovirus B19, especially if there is notice of an ongoing outbreak of erythema infectiosum.