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Drug discovery and development using chemical genomics
1ChemGenex Therapeutics Inc, Molecular Biology and Genomics, 3475 M Edison Way, Menlo Park, CA 94025, USA. asehgal@chemgenex.com
Current Opinion in Drug Discovery & Development
|August 29, 2002
Summary
Chemical genomics accelerates drug discovery by integrating chemistry with genomics and proteomics. This approach reduces drug failure risk and expands potential therapeutic targets, speeding up development.
Area of Science:
- Genomic Medicine
- Chemical Biology
Background:
- The human genome sequence provides a vast resource for identifying new therapeutic targets.
- Traditional drug development is lengthy, taking 8-10 years per target, potentially delaying the use of new medicines.
Purpose of the Study:
- To introduce chemical genomics as a strategy to accelerate drug development.
- To highlight how integrating chemistry early can improve target identification and reduce failure rates.
Main Methods:
- Utilizing genomics and proteomics data.
- Employing combinatorial chemistry and cell-based screening.
- Integrating chemical approaches early in the drug discovery pipeline.
Main Results:
- Chemical genomics significantly speeds up the drug development process.
- This approach enhances the identification of potential drug targets.
- It also serves to mitigate the risk of drug candidate failure.
Conclusions:
- Chemical genomics represents a paradigm shift in drug discovery.
- Early integration of chemistry accelerates the conversion of genomic knowledge into therapeutics.
- This strategy broadens the scope of druggable targets and improves development efficiency.