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Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies
1Department of Anesthesia and Perioperative Care, Room S-455i, Box 0464, University of California, San Francisco, CA 94143-0464, USA. sonnerj@anesthesia.ucsf.edu
Anesthesia and Analgesia
|August 29, 2002
Abstract
Implications:
The two experimental designs (quantal and bracketing) used for population minimum alveolar anesthetic concentration studies give equivalent results. An expression relating variability in terms of Hill coefficients and SD is presented. Evolutionary implications of low population variability in anesthetic phenotypes is discussed.