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Assessment of repeatability and correlates of arterial compliance
L Michael Prisant1, Mohit Pasi, Dena Jupin
1Hypertension and Clinical Pharmacology, Medical College of Georgia, Augusta 30912, USA. mprisant@mail.mcg.edu
Insights
Arterial elasticity measurements using the HDI/Pulsewave CR-2000 system show good repeatability over short and intermediate periods. Non-invasive readings align well with invasive hemodynamic assessments.
Area of Science:
- Cardiovascular Physiology
- Medical Device Technology
Background:
- Arterial elasticity is a key indicator of cardiovascular health.
- Accurate and repeatable non-invasive measurement of hemodynamic parameters is crucial for clinical practice.
Purpose of the Study:
- To assess the repeatability of large (C1) and small (C2) arterial elasticity indices measured by the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System.
- To compare non-invasive hemodynamic parameters obtained from this device with invasive measurements.
Main Methods:
- Healthy hospital employees (n=31) underwent two cardiovascular profiles within 1 hour.
- Another group (n=59) had profiles approximately 52 days apart.
- A separate group (n=23) had invasive (cardiac catheterization) and non-invasive hemodynamic assessments.
Main Results:
- Short-term repeatability (within 1 hour) showed minimal mean differences for C1 (+0.25 +/- 2.83) and C2 (-0.14 +/- 1.86).
- Intermediate-term repeatability (52 days) also demonstrated low mean differences for C1 (-0.415 +/- 2.97) and C2 (-0.19 +/- 2.67).
- Invasive measurements yielded significantly lower aortic diastolic blood pressure and systemic vascular resistance compared to non-invasive readings.
Conclusions:
- The HDI/Pulsewave CR-2000 system provides repeatable measurements of arterial elasticity over short and intermediate timeframes.
- Non-invasive hemodynamic parameters obtained using this device demonstrate reasonable agreement with invasive measurements.
Objectives:
The aim of these studies was to assess repeatability of large (C1) and small (C2) arterial elasticity indices over various time intervals using the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System (Hypertension Diagnostics, Inc., Eagan, Minnesota, USA). Non-invasive hemodynamic parameters using this device were compared to invasive measurements.
Methods:
After a 5-min period of rest, 31 healthy hospital employees underwent cardiovascular profiling on two occasions within 1 h apart. Another 59 healthy hospital employees underwent cardiovascular profiling on two occasions, an average 52 days apart. An additional group of 23 patients underwent right and left heart catheterizations for routine clinical indications and hemodynamic assessment was performed invasively and non-invasively.
Results:
For short-term repeatability, the mean difference of C1 was +0.25 +/- 2.83 ml/mmHg x 10 (P = NS) and C2 was -0.14 +/- 1.86 ml/mmHg x 100 (P = NS). For intermediate test repeatability, the mean difference of C1 was -0.415 +/- 2.97 ml/mmHg x 10 (P = NS) and C2 was -0.19 +/- 2.67 ml/mmHg x 100 (P = NS). In the invasive protocol, both aortic diastolic blood pressure (-4.74 +/- 9.7 mmHg) and systemic vascular resistance (-194 +/- 264 dyne x s x cm(-5)) were significantly lower invasively.
Conclusions:
Measurements with the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System are repeatable over both a short and intermediate period of observation. Furthermore, non-invasive hemodynamic parameters reasonably agree with invasive measurements.