Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

+1 Proteins and aging.

F W van Leeuwen1, L Gerez, R Benne

  • 1Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands.

The International Journal of Biochemistry & Cell Biology
|August 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

NPJ schizophrenia·2018
Same author

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies.

Translational psychiatry·2017
Same author

Characterizing primary human microglia: A comparative study with myeloid subsets and culture models.

Glia·2016
Same author

Polyglutamine aggregation in Huntington's disease and spinocerebellar ataxia type 3: similar mechanisms in aggregate formation.

Neuropathology and applied neurobiology·2015
Same author

The GOSTT concept and hybrid mixed/virtual/augmented reality environment radioguided surgery.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2014
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Errors in RNA, called molecular misreading, can create mutated proteins. These +1 proteins, like ubiquitin(+1), may accumulate with aging and contribute to diseases such as Alzheimer's disease.

Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Molecular misreading generates errors in RNA, leading to mutated protein production.
  • Dinucleotide deletions in mRNA simple sequence repeats can cause frameshift mutations during translation.
  • These errors result in the synthesis of '+1' proteins, which may have altered or lost function.

Purpose of the Study:

  • To investigate the phenomenon of molecular misreading and its consequences.
  • To explore the role of '+1' proteins, such as ubiquitin(+1) (UBB(+1)), in cellular processes.
  • To hypothesize the link between impaired quality control, '+1' protein accumulation, and age-related diseases like Alzheimer's disease (AD).

Main Methods:

  • Analysis of mRNA sequences for dinucleotide deletions in simple sequence repeats.

Related Experiment Videos

  • Investigation of the functional consequences of '+1' protein production, using UBB(+1) as a model.
  • Examination of the accumulation of '+1' proteins in neuropathological hallmarks of AD.

    • Main Results:

    • Dinucleotide deletions (delta GA, delta GU) were identified in mRNA simple sequence repeats.
    • The resulting '+1' proteins, exemplified by UBB(+1), exhibit loss of function (e.g., impaired ubiquitination).
    • UBB(+1) accumulation was observed in Alzheimer's disease pathology, suggesting a potential role in the disease.

    Conclusions:

    • Molecular misreading can produce non-functional '+1' proteins that escape quality control.
    • Impaired RNA and protein quality control during aging may lead to the manifestation of '+1' proteins.
    • Accumulation of '+1' proteins, such as UBB(+1), is implicated in the pathogenesis of age-related diseases, including Alzheimer's disease.