Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

Sinisa Urban1, Matthew Freeman

  • 1MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK. sin@mrc-lmb.cam.ac.uk

Current Opinion in Genetics & Development
|August 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A sterol-binding pocket in iRhom1 underlies paralog-specific regulation of the sheddase ADAM17.

bioRxiv : the preprint server for biology·2026
Same author

Strain-level analyses of public sequencing data to characterize <i>Escherichia coli</i> strain sharing between children and chickens in Mozambique.

One health (Amsterdam, Netherlands)·2026
Same author

Deleterious Mutations in the Mitogenomes of Cetacean Populations.

Biology·2026
Same author

Evaluation of Atmospheric Preprocessing Methods and Chlorophyll Algorithms for Sentinel-2 Imagery in Coastal Waters.

Remote sensing·2026
Same author

Prescriptions for Connection-Social Prescribing for Older People in Australia: Protocol for a Feasibility Study.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Quality of life for middle and older aged people with chronic conditions in primary care: a cross-sectional study.

BMC primary care·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Regulated intramembrane proteolysis (RIP) is a key cell signaling mechanism. This process controls both intracellular transcription factors and intercellular communication factors.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Regulated intramembrane proteolysis (RIP) is a conserved biological process.
  • RIP controls signaling pathways in prokaryotes and eukaryotes.
  • Early RIP research focused on intracellular signaling.

Purpose of the Study:

  • To explore the role of RIP in intercellular communication.
  • To expand the understanding of RIP's function beyond intracellular signaling.

Main Methods:

  • Literature review and analysis of recent studies on RIP.
  • Comparative analysis of RIP mechanisms in different organisms.

Main Results:

  • RIP regulates the activation of membrane-tethered transcription factors.

Related Experiment Videos

  • Recent findings show RIP also controls the release of signaling molecules for intercellular communication.

    • Conclusions:

    • RIP is a versatile mechanism with dual roles in intracellular and intercellular signaling.
    • Further research into RIP's role in cell-to-cell communication is warranted.