Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infarct scar as living tissue.

Yao Sun1, Mohammad F Kiani, Arnold E Postlethwaite

  • 1Division of Cardiovascular Diseases, University of Tennessee, Health Science Center, Rm 353 Dobbs Research Institute, 951 Court Avenue, Memphis, TN 38163, USA.

Basic Research in Cardiology
|August 30, 2002
PubMed
Summary

Infarct scar tissue is not inert but a dynamic, living tissue. This living scar, with active cells and new blood vessels, is crucial for understanding and potentially regenerating heart tissue after myocardial infarction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives.

Cells·2026
Same author

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics.

Frontiers in immunology·2025
Same author

Optimizing oral immune tolerance to Type II collagen in patients with rheumatoid arthritis: The importance of dose, interfering medication and genetics.

The American journal of the medical sciences·2024
Same author

Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity.

Frontiers in immunology·2024
Same author

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and <i>in silico</i> modeling to identify new therapeutics.

Frontiers in cellular and infection microbiology·2024
Same author

LEUKOCYTE PHENOTYPING IN SEPSIS USING OMICS, FUNCTIONAL ANALYSIS, AND IN SILICO MODELING.

Shock (Augusta, Ga.)·2022

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cardiac Pathophysiology

Background:

  • Historically, infarct scar tissue was viewed as acellular collagen, solely for structural support after myocardial infarction.
  • This traditional view is being challenged by new cellular and molecular biology insights.

Purpose of the Study:

  • To review the dynamic components of infarct scar tissue.
  • To highlight the relevance of scar tissue's living nature for preventing heart failure and promoting myocardial regeneration.

Main Methods:

  • Review of current cellular and molecular biology findings.
  • Analysis of the composition and function of infarct scar tissue.

Main Results:

  • Infarct scar is recognized as living tissue, not inert.

Related Experiment Videos

  • It contains active fibroblast-like cells regulating collagen turnover and contraction.
  • The scar is supported by newly formed blood vessels (neovasculature).

    • Conclusions:

    • The dynamic nature of infarct scar tissue is critical for cardiac repair.
    • Understanding these living components is essential for developing strategies to prevent heart failure and regenerate myocardial tissue.