Related Experiment Video

Updated: Jul 28, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

Short-term omeprazole treatment does not influence biochemical parameters of bone turnover in children

I Kocsis1, A Arató, H Bodánszky

  • 1First Department of Pediatrics, Semmelweis University, Budapest Bókay u. 53, H-1083, Hungary. kopist@gyer1.sote.hu

Calcified Tissue International
|August 30, 2002
PubMed

Insights

Short-term omeprazole use in children did not affect bone turnover markers. This study found no significant impact on osteoclast or osteoblast function in pediatric patients receiving proton pump inhibitors.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Bone Metabolism

Background:

  • Proton pump inhibitors (PPIs) like omeprazole are common for acid-related disorders.
  • Data on PPIs' effects on pediatric bone metabolism, specifically osteoclast function, are limited.

Purpose of the Study:

  • To investigate the impact of short-term omeprazole administration on biochemical markers of bone turnover in children.
  • To assess omeprazole's influence on osteoclast and osteoblast activity in a pediatric cohort.

Main Methods:

  • 34 pediatric patients received 20 mg/day omeprazole for 2 weeks.
  • Biochemical parameters of bone turnover were measured pre- and post-treatment.
  • Assessed parameters included urinary calcium, alkaline phosphatase, CTX-1, and osteocalcin.

Main Results:

  • All measured bone turnover markers remained within normal reference ranges for all participants.
  • No significant alterations in these biochemical parameters were observed across different ages or genders.
  • Short-term omeprazole treatment did not significantly affect the investigated bone turnover markers.

Conclusions:

  • Omeprazole, at a dosage of 20 mg/day, does not appear to significantly impact key biochemical markers of bone turnover in pediatric patients.
  • These findings suggest that short-term PPI use is unlikely to adversely affect osteoclast or osteoblast function in children.

More Related Videos

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments06:16

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...