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Characteristic profile of intestinal microflora in Kawasaki disease
S Takeshita1, I Kobayashi, Y Kawamura
1Department of Pediatrics, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan. peditake@me.ndmc.ac.jp
Unlabelled:
To investigate whether the ecology of the intestinal microflora may change in the acute phase of Kawasaki disease (KD), the distribution pattern was studied of common micro-organisms in feces from 20 patients with KD, 20 patients with acute febrile diseases (disease control) and 20 healthy children. KD patients had a significantly lower (p < 0.001) incidence of Lactobacillus (2/20, 10%) than disease control patients (16/20, 80%) and healthy children (14/20, 70%). KD patients had no significant incidences of other microbial genera, compared with both disease control and healthy children.
Conclusion:
The results suggest that a lack or loss of the beneficial Lactobacillus genus in the enteric microflora may occur during the acute phase of KD.