Formation of ionization clusters in nanometric structures of propane-based tissue-equivalent gas or liquid water by...

Despite the importance of ionization yield formation in sub-cellular structures a few nanometres in size, with regard to radiation damage our present knowledge in this respect is almost exclusively based on Monte Carlo simulations which in turn are based on cross section sets for water vapour or liquid water. Experimental data, although urgently needed, are still missing because the direct measurement of ionization yields in sub-cellular structures or, at least, in nanometric volumes of liquid water, is not yet possible. The best feasible way to overcome this problem of measurement at present, is the use of highly sophisticated counters filled with gases at low operating pressure to simulate target volumes a few nanometres in diameter at unit density. An indispensable prerequisite of the reliability of such measurements is, however, a check of the equivalence of the ionization yield produced in a specified target gas and the yield to be expected in liquid water or biological material. For this purpose, the ionization yield formation by electrons and alpha-particles in liquid water was simulated using the Monte Carlo method and compared with that produced in propane-based tissue-equivalent gas (composition by volume 55% C3H8, 39.6% CO2, 5.4% N2). After a short summary of the most important physical aspects of ionization cluster formation, new results are presented and discussed from the point of view of radiation physics and radiation biology.