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Rising quinolone resistance in Neisseria gonorrhoeae isolates from New Delhi
P Bhalla1, S Vidhani, B S N Reddy
1Departments of Microbiology & Skin & STD, Maulana Azad Medical College & Associated, Lok Nayak Hospital, New Delhi, India.
The Indian Journal of Medical Research
|August 31, 2002
Summary
Ciprofloxacin resistance in Neisseria gonorrhoeae is increasing in New Delhi. This study found 75% of isolates resistant to ciprofloxacin, highlighting the need for ongoing antimicrobial susceptibility monitoring.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Fluoroquinolones are recommended for gonorrhoea treatment.
- Emerging fluoroquinolone resistance and treatment failures have been reported.
- Neisseria gonorrhoeae (N. gonorrhoeae) poses a significant public health challenge.
Purpose of the Study:
- To investigate the antibiotic susceptibility patterns of N. gonorrhoeae isolates.
- To determine the incidence of quinolone resistance in N. gonorrhoeae.
- To assess resistance to ciprofloxacin in New Delhi isolates.
Main Methods:
- Collected 36 consecutive N. gonorrhoeae isolates from male patients.
- Performed Kirby Bauer disc diffusion and agar dilution methods for susceptibility testing.
- Identified penicillinase-producing N. gonorrhoeae (PPNG) using nitrocefin disc method.
Main Results:
- Only 8.3% of isolates were sensitive to ciprofloxacin by disc diffusion.
- 75% of isolates exhibited ciprofloxacin resistance based on MIC determination.
- Sensitivity varied for other antibiotics: 63.9% to tetracycline, 33.3% to penicillin.
- 11.1% of isolates were identified as PPNG.
Conclusions:
- Ciprofloxacin resistance in N. gonorrhoeae is rising in New Delhi.
- Continuous monitoring of antimicrobial susceptibility is crucial.
- Alternative antibiotics may be needed to prevent gonorrhoea treatment failure.