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Related Experiment Videos

A transmissible human endogenous retrovirus.

Tove Christensen1, Lene Pedersen, Pernille D Sørensen

  • 1Department of Medical Microbiology and Immunology, University of Aarhus, DK-8000 Aarhus C, Denmark. tc@microbiology.au.dk

AIDS Research and Human Retroviruses
|August 31, 2002
PubMed
Summary
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The human endogenous retrovirus HERV-H/RGH-2, linked to multiple sclerosis (MS), was found to be transmissible between cells. This study provides evidence for the low-level spread of this retrovirus in vitro.

Area of Science:

  • Virology
  • Immunology
  • Neuroscience

Background:

  • Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections in the human genome.
  • HERV-H/RGH-2 is a specific HERV family associated with multiple sclerosis (MS).
  • Previous work demonstrated HERV-H variants in MS patient samples.

Purpose of the Study:

  • To investigate the transmissibility of the human endogenous retrovirus HERV-H/RGH-2.
  • To determine if HERV-H/RGH-2 can be transmitted between cells in a laboratory setting.

Main Methods:

  • Marker rescue experiments involving co-cultivation of HERV-H/RGH-2 producing cells with indicator cells.
  • Assays for productive infection, including reverse transcriptase activity.
  • Detection of retroviral vector construct rescue in indicator cells.

Related Experiment Videos

Main Results:

  • The human endogenous retrovirus HERV-H/RGH-2 demonstrated transmissibility between cell cultures.
  • Transmission occurred at a very low level.
  • Evidence of productive infection and vector rescue confirmed transmissibility.

Conclusions:

  • The human endogenous retrovirus HERV-H/RGH-2 is transmissible.
  • This finding supports the potential role of HERV-H/RGH-2 in the pathogenesis of multiple sclerosis.
  • Further research is warranted to understand the in vivo implications of HERV-H/RGH-2 transmissibility.