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Increased bladder apoptosis with alpha-1 adrenoceptor antagonists in benign prostatic hyperplasia
T Erdoğru1, K H Gülkesen, E Kukul
1Department of Urology, Akdeniz University Faculty of Medicine, Antalya, Turkey. drtibet@netone.com.tr
Scandinavian Journal of Urology and Nephrology
|August 31, 2002
Summary
Preoperative alpha-1 adrenoceptor antagonists (alpha-1ARA) increased bladder wall apoptosis, potentially aiding hypertrophy control. However, this did not significantly improve postoperative irritative symptoms after bladder outlet obstruction removal.
Area of Science:
- Urology
- Cell Biology
- Pharmacology
Background:
- Bladder outlet obstruction (BOO) causes detrimental changes in bladder wall components.
- Understanding the role of apoptosis and proliferation in BOO is crucial for therapeutic strategies.
Purpose of the Study:
- To investigate if alpha-1 adrenoceptor antagonists (alpha-1ARA) prevent BOO-induced bladder wall alterations.
- To assess if alpha-1ARA treatment improves irritative symptoms post-BOO relief.
Main Methods:
- A study involving 39 patients divided into untreated and alpha-1ARA treated groups.
- Apoptotic and proliferative indices of bladder wall components were measured using TUNEL assay and PCNA immunoreactivity.
Main Results:
- Alpha-1ARA treatment significantly increased apoptotic indices in lamina propria and myofibroblast cells.
- No significant difference in postoperative symptom indices was observed between treated and untreated groups.
Conclusions:
- Preoperative alpha-1ARA may modulate bladder wall hypertrophy and supersensitivity by balancing apoptosis and proliferation.
- Further research is needed to confirm long-term alpha-1ARA effects on postoperative irritative symptoms.