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Updated: Aug 14, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
[Weekly Taxol (Paclitaxel) administration in the second-line treatment of breast cancer]
1Radiológiai és Onkoterápiás Klinika, Semmelweis Egyetem AOK, Budapest, 1082, Hungary.
Abstract:
Based on phase II and III trials Taxol administered in the form of three times/week 1 or 3 hr infusion as mono-or combined chemotherapy of breast cancer is an effective treatment option. These studies proved that this form of drug delivery is effective and well tolerated and the overall response rate is around 50%. The 1 hr weekly infusion of Taxol is an effective second-line treatment in metastatic breast cancer and is better than the 3-weekly infusion since the decreased toxicity increases the therapeutic index.
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