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Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamine
F C Pereira1, S Z Imam, B Gough
1Neurochemistry Laboratory, Division of Neurotoxicology, NCTR, Jefferson 72079, AR, USA.
Journal of Neural Transmission (Vienna, Austria : 1996)
|August 31, 2002
Abstract:
Acute changes in dopamine (DA) turnover were studied in the caudate nucleus (CN) of adult male rats between 0-24 h after a single injection of Methamphetamine (20 mg/kg, ip). A single dose of METH-induced an increase in DA turnover [(DOPAC + HVA)/DA] concomitant with an acute DA release followed by transient DA and DOPAC depletion in the rat CN.