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Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
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Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamine

F C Pereira1, S Z Imam, B Gough

  • 1Neurochemistry Laboratory, Division of Neurotoxicology, NCTR, Jefferson 72079, AR, USA.

Journal of Neural Transmission (Vienna, Austria : 1996)
|August 31, 2002
PubMed

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Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...