[Permeability enhancement by exudates: 1. Demonstration of high-molecular substances in the animal model]

By means of ultracentrifugation, gel chromatography and polyacryl amide electrophoresis the peritoneal exudates of the rabbit, which increased the permeability of animal membranes, were separated. Among the highly molecular fractions two regions were found, which possessed an activity increasing permeation. Following the chromatographic separation of exudates of the rabbit, which did not reveal an activity increasing permeation, were also found two regions with an activity increasing permeation. The cuases for the activation during the separation process are discussed.