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A stable DNA duplex containing a non-hydrogen-bonding and non-shape-complementary base couple: interstrand stacking
C Brotschi1, A Häberli, C J Leumann
1Department of Chemistry and Biochemistry, University of Bern Freiestrasse 3, 3012 Bern, Switzerland, Fax: (+41) 31-631-3422.
Angewandte Chemie (International Ed. in English)
|August 31, 2002
Abstract:
The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).