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Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles
Wusheng Yin1, Emmanuel O Akala, Robert E Taylor
1Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, 2300 4th Street, NW, Washington, DC 20059, USA.
International Journal of Pharmaceutics
|September 3, 2002
Summary
Researchers developed novel hydrolyzable crosslinked nanoparticles for sustained naltrexone release. The nanoparticle composition influenced drug release duration, offering potential for controlled drug delivery applications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Nanotechnology
Background:
- Hydrolyzable crosslinkers are crucial for developing degradable polymer networks.
- Naltrexone delivery systems require controlled release mechanisms for therapeutic efficacy.
Purpose of the Study:
- To synthesize and characterize a novel hydrolyzable crosslinker, N,O-dimethacryloylhydroxylamine (MANHOMA).
- To prepare and characterize naltrexone-loaded nanoparticles using MANHOMA as a crosslinker.
- To investigate the in vitro drug release profile of naltrexone from these nanoparticles.
Main Methods:
- Synthesis of MANHOMA via a modified method, characterized by 1H-NMR, FTIR, and melting point.
- Nanoparticle preparation through copolymerization of PEO-MA, MMA, and MANHOMA.
- Characterization of nanoparticles using FTIR, particle size analysis, and Transmission Electron Microscopy (TEM).
- In vitro drug loading efficiency and drug release studies.
Main Results:
- Successful synthesis and characterization of MANHOMA.
- TEM images revealed nanoparticles with a crosslinked core and a PEO-MA corona.
- Naltrexone-loaded nanoparticles demonstrated sustained drug release.
- Drug release kinetics were dependent on the monomer feed composition.
Conclusions:
- Novel hydrolyzable crosslinked nanoparticles were successfully fabricated.
- The developed nanoparticles show potential for sustained naltrexone delivery.
- Monomer composition is a key factor in controlling drug release rates.