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Synthesis of ceramidated GLA-60 derivatives
Tsuyoshi Nakamura1, Masao Shiozaki, Shin-ichi Kurakata
1Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan.
Carbohydrate Research
|September 3, 2002
Abstract:
Ceramidated GLA-60 derivatives 11 and 11' were synthesized from 1 via glycosidation of ceramide derivative 12 as a glycosyl acceptor with GLA-60 derivative 5 as a glycosyl donor, and successive conversion. Compound 11' showed only weak LPS-antagonistic activity without showing any LPS-agonistic activity.